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Dengue Treatment
Although there is no specific drug to treat this disease, if treatment is currently based on clinical manifestations has been shown to reduce mortality. The new WHO guidelines provide for three treatment groups:
Group A: Patients can be sent home because they have no hemodynamic changes do not belong to a risk group and have no warning signs. The management is based on increasing oral fluid intake is recommended to prevent dehydration . To relieve pain and fever is very important to avoid aspirin and nonsteroidal anti-inflammatory drugs , since these drugs can worsen the bleeding associated with some of these infections, for its anticoagulant effects, in place, patients should take paracetamol (acetaminophen) for the management of fever and pain.
Group B: Patients with signs of alarm and / or belong to a risk group. Such patients require hospitalization for at least 72 hours to intravenous fluid resuscitation, close monitoring of vital signs, urine output and measurement of hematocrit .
Group C: patients with a diagnosis of severe dengue, which require management in intensive care units.
The search for specific treatments for the disease has led scholars to conduct studies to reduce up replication of the virus, which is related to the severity of clinical manifestations. There are several clinical trials where one considers the pathophysiology of the disease, suggesting that they have serious clinical history of exposure to the virus, which generates an immune memory. This memory through contact with the virus in a second exposure triggers an exaggerated immune response. Given this explanation of the pathophysiology, medications suggests that the immune response modularores as steroids , chloroquine , mycophenolic acid and ribavirin inhibit the replication of the virus. However, these studies are not conclusive and is not recommended use today.
